Ewing’s U is a webinar where Ewing Sarcoma experts share their research, hope, and innovation.
This webinar is for physicians, researchers, warriors, caregivers, and curious minds. All are welcome.
Sign up to get email notifications of upcoming episodes of Ewing’s U.
Dr. Holly Meany (at Children's National Hospital) presents the upcoming SABRE Trial (NCT07172958), a phase I dose-escalation study to determine the safety and feasibility of autologous CAR-TA T cells (B7-H3 CAR+ T cells administered with DNR-PRAME Tumor Antigen-specific T cells) following lymphodepleting chemotherapy in participants with relapsed/refractory rhabdomyosarcoma, Ewing sarcoma, neuroblastoma and Wilms tumor.
Dr. David Loeb (Children's Hospital at Montefiore) makes a repeat guest appearance to present and discuss an upcoming Phase II Clinical Trial centered around DFMO for Ewing sarcoma and Osteosarcoma.
Dr. Maggie Fader (at Nicklaus Children's Hospital) discusses the ongoing Functional Precision Medicine Clinical Trial for relapsed or refractory pediatric cancer patients (NCTNCT05857969). This webinar will outline this team's unique approach to personalized medicine, utilizing patient specific ex vivo Drug sensitivity Testing (DST) and genomic profiling.
Dr. Christine Heske (at NCI) discusses the recently opened PEN-866 (or VTPEN) clinical trial for relapsed and refractory AYA with Ewing or Rhabdomyosarcoma (NCT04890093). We'll discuss the preclinical science behind this trial, key distinguishing features of the newly opened trial, and how patient advocacy and persistence made this trial a reality.
Join us as we head to the other side of the pond, with trial lead Dr. Bernadette Brennan (Royal Manchester Children’s Hospital), to take look at a multi-arm and new clinical trial called INTER-EWING-1 (https://www.bcrt.org.uk/information/clinical-trials/recruiting-clinical-trials/inter-ewing-1).
Dr. Rashmi Chugh (University of Michigan) presents a phase I trial for Ewing sarcoma, centered around a new targeted agent called INBRX-109. INBRX-109 is a recombinant humanized tetravalent antibody targeting human death receptor 5 (DR5). This targeted agent will be given in combination with Irinotecan and Temozolomide.
Dr. Matteo Trucco (Cleveland Clinic) discusses a new upfront trial for Metastatic Ewing sarcoma. METTSEO (Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes) will test the ability to administer frequently changing chemotherapy regimens, based on evolutionary biology principles called sequential second strikes, to patients with widely metastatic Ewing sarcoma in order to stop development of resistance to chemotherapy and improve cure rates.
Dr. David Shulman (Dana Farber Cancer Institute) discusses the newly opened PEEL-224 Phase I/II Clinic Trial (NCT06709495) for relapse or refractory sarcomas in AYAs. PEEL-224 is newly formulated Topoisomerase I Inhibitor with preclinical efficacy as a single agent. For this clinical trial, PEEL-224 will combined with Vincristine and Temozolomide (V, P, T).
Dr. Brian Crompton (at Dana Farber Cancer Institute) discusses the ongoing research behind liquid biopsy detection of Ewing sarcoma cells and ongoing efforts to leverage this technology to risk stratify patients at diagnosis, with the ultimate aim of changing the trajectory of cancer treatment on individual basis.
Join us for this special "trifecta" presentation and discussion on NK cell therapy in pediatric sarcomas. Dr. Dean Lee (Nationwide Children's Hospital) will provide an overview of NK cell therapy, Dr. Bhuvana Setty (Nationwide Children's Hospital) will provide an update on the ongoing TiNKs trial (NCT05634369), and Dr. Wen Luo (New York Medical College) will provide a preview into promising research centered around next generation NK cell therapies (CAR-NK, etc.) for Ewing sarcoma.
In this episode of Ewing’s U, Dr. Chandrika Behura (at Penn State Health Children's Hospital) discusses the research behind a new CK2 inhibitor for solid tumors (including Ewing sarcoma) and shares details about a new clinical trial (BCC021) through the Beat Childhood Cancer Research Consortium.
In this webinar, we'll hear from pediatric radiation oncologist Dr. Matthew Ladra of Children’s National Medical Center (affiliated with Johns Hopkins Sidney Kimmel Cancer Center) on proton radiation and discuss when and how proton radiation therapy might be the best option for local control in Pediatric Sarcomas, with a focus on metastatic disease.
Pediatric oncologist Dr. Filemon Dela Cruz of MSK discusses how cutting-edge Tumor Sequencing and Bionformatics paired with AI modeling can help find druggable master regulators (chokepoints) in Ewing Sarcoma.
Orthooncologist Dr. Thomas Scharschmidt of Nationwide Children's discusses multiple cutting-edge surgical options that are now available to kids with Ewing Sarcoma, with the ultimate aim of using modern technology to improve patient outcomes.
Dr. Federico provided updates on two unique clinical trials underway at St. Jude Children’s Research Hospital: ONITT and Angio-A.
Dr. Loeb shared the results of his research in animal models and talked about the potential of this drug for Ewing Sarcoma.
Dr. Grohar provides an update on Phase I results of SARC037 – a clinical trial of Trabectedin in combination with Irinotecan. We also touch on the recently opened study at CHOP utilizing a similar targeted agent, Lurbinectedin.
Warrior Mom turned Researcher Janet Panoch PhD discusses her newly released Surgical Decision Aid. Although geared specifically towards Osteosarcoma, this decision aid is equally applicable to those with Ewing Sarcoma.
We spoke with talk with Dr. Erin Trovillion about the clinical side of the In:Formation Project, a precision medicine program. We were also fortunate to be joined the parents of an 11 year-old who is enrolled in the In:Formation Project.
In February, we talked to Dr. Margolis of Children’s Wisconsin about the use of Bone Marrow Transplant as a treatment option for Ewing Sarcoma. We heard about factors to consider, approaches, and expectations.
Dr. Claudia Rössig joined Ewings U to discuss her novel CAR-T Therapy development for Ewing Sarcoma.
Previous CAR-T research has fallen short for Ewing Sarcoma patients. However, Dr. Rössig's lab has identified a promising new approach that will be entering a Phase I Clinical Trial this year.
Dr. Nelson speaks with the Little Warrior Foundation about Cryoablation in solid tumors and the innovative clinical trial she is leading at Children’s National Medical Center. (Clinical Trial: NCT05302921)
Dr. Matteo Trucco discussed the National Ewing Sarcoma Tumor Board with the Little Warrior Foundation Co-Founders.
Dr. Ramon Sun discusses how his lab uses cutting-edge analytical techniques to discover a unique metabolic dependency of Ewing's Sarcoma cells, and how this newfound knowledge has led to further preclinical research that exploits this metabolic vulnerability, significantly reducing the growth rate of Ewing Sarcoma tumor cells.
EPISODE THREE: On August 9, 2022, The Little Warrior Foundation + Dr. Erin Murphy of the Cleveland Clinic discussed the use of SBRT in pediatric sarcoma patients. This post contains video, transcript and patient resources.
EPISODE TWO: On June 9, 2022, The Little Warrior Foundation + Dr. Pete discussed his perspective on how to interpret labs, scans and pathology. This post contains video, transcript and patient resources.
EPISODE ONE: On May 12, 2022, The Little Warrior Foundation + Giselle Sholler, MD discussed the role of advanced genomic sequencing, precision medicine for Ewing Sarcoma. Dr. Sholler also outlined the incredible IN:Formation Project.
This post contains video, transcript and patient resources.
Drs. Eric Rowinsky and James Tonra of Seed Therapeutics present on recently opened clinical trial (NCT07197554) for solid tumor, with specific focus on Ewing sarcoma. ST-01165 is a orally administered, protein degrader (molecular glue), targeting RMB39 - a key regulator of RNA splicing and transcription required for tumor cell proliferation.